Home
Currency:USD
Language: en

ED RX Medications

0
You have no items in your shopping cart.

0

Currency: USD
Language: English

Welcome to our online pharmacy!

Vega Extra Cobra (sildenafil citrate)

Vega Extra Cobra (sildenafil citrate)

$ 1.02 per pill

Quick Overview

Selective Vega Extra 120 against PDE5 in vitro, its activity against PDE5 superior activity against other known PDE isoenzymes: PDE-6 — 10 times; PDE-1 more than 80 times; PDE-2, PDE-4, PDE-7 PDE–11 more than 700 times. Vega Extra 120 is 4000 times more selective for PDE-5 than PDE-3, which is crucial because PDE-3 is one of the key enzymes in the regulation of myocardial contractility.

Vega Extra Cobra® (Signature)

Vega Extra Cobra (Sildenafil citrate) 120 mg

Vega Extra Cobra
Sildenafil citrate
120 mg × 180 pills
$ 193.90 $ 183.95
$ 1.02 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 120 pills
$ 160.90 $ 151.95
$ 1.27 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 90 pills
$ 145.90 $ 137.95
$ 1.53 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 60 pills
$ 115.90 $ 109.95
$ 1.83 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 30 pills
$ 67.90 $ 63.95
$ 2.13 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 20 pills
$ 49.90 $ 46.95
$ 2.35 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 10 pills
$ 27.90 $ 25.95
$ 2.59 per pill
Buy

Information

Vega Extra 120 is a potent selective inhibitor of cGMP-specific PDE-5.



Mechanism of action

The implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in the cavernous body during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, the subsequent relaxation of smooth muscle tissue of the cavernous body and an increase in blood flow.

Extra Vega does not have a direct relaxing effect on the isolated cavernous human body, but enhances the effect of nitric oxide by inhibiting PDE-5, which is responsible for the disintegration of cGMP.

Selective Vega Extra 120 against PDE5 in vitro, its activity against PDE5 superior activity against other known PDE isoenzymes: PDE-6 — 10 times; PDE-1 more than 80 times; PDE-2, PDE-4, PDE-7 PDE–11 more than 700 times. Vega Extra 120 Mg is 4000 times more selective for PDE-5 than PDE-3, which is crucial because PDE-3 is one of the key enzymes in the regulation of myocardial contractility.

A prerequisite for the effectiveness of Sildenafil Vega Extra 130 Mg is sexual stimulation.

Vega Extra 120 restores impaired erectile function in conditions of sexual stimulation by increasing blood flow to the cavernous bodies of the penis.

The pharmacokinetics of Sildenafil Vega Extra 130 Mg Cobra in the recommended dose range is linear.

Suction. After intake of Vega Extra 120 is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Vega Extra 120 Mg at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Vega Cobra 120 100 mg average Cmax free Vega Extra Strong 120 in plasma men is about 18 ng/ml (38 nm). Cmax when taking Vega Extra 120 inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Extra Vega is 105 l. the Association of Cobra Vega 120 Mg and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Cobra Vega (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Vega Extra 120 is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Vega Extra 120, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Vega Extra 120, and its activity against PDE-5 in vitro is about 50% of the activity of Vega Visa. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Vega Extra 120. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Vega Extra 120 is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Vega Extra 120 is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Cardiovascular complications

During the post-marketing use of Vega Extra 120 for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) were reported, which had a temporary connection with the use of Sildenafil Vega Extra 130. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events were observed shortly after sexual activity, and some were observed after taking Vega Extra 120 without subsequent sexual activity. It is not possible to establish a direct link between the reported adverse events and those or other factors.

Hypotension

Vega Coin has a systemic vasodilating effect, leading to a transient decrease in blood PRESSURE, which is not clinically significant and does not lead to any consequences in most patients. However, before prescribing Vegah Extra 130, the doctor should carefully assess the risk of possible undesirable manifestations of vasodilating action in patients with relevant diseases, especially against the background of sexual activity. Increased susceptibility to vasodilators is observed in patients with obstruction of the output tract of the left ventricle (aortic stenosis, GOCMP), as well as with the rare syndrome of multiple systemic atrophy, manifested by a severe violation of the regulation of blood PRESSURE from the autonomic nervous system.

Since the combined use of Vegah Extra 120 Mg and α-blockers can lead to symptomatic hypotension in some sensitive patients, Vega Extra Cobra 130 Mg should be used with caution in patients taking α-blockers (see "Interaction"). To minimize the risk of postural hypotension in patients taking α-blockers, the drug Vega Extra 120 should be started only after achieving stabilization of hemodynamic parameters in these patients. It should also consider reducing the initial dose of Vega Extra 120 (see. "Dosage and administration"). The doctor should inform patients about what actions should be taken in case of symptoms of postural hypotension.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Sildenafil Tablets Vega Extra Cobra, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Vega Pills therapy in case of sudden loss of vision and consult a doctor immediately.

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Vega Coin, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Vega Extra 120 is contraindicated (see "Contraindications").

A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of the PDE of the retina. Information about the safety of the drug Vega Extra 120 in patients with retinitis pigmentosa absent, so these patients should not be used Vega Extra 120 (see "Contraindications").



Sildenafil Vega Extra 130 Mg Cobra

Reviews

Vega-extra88 out of100 with37 ratings
Vega-extraI have gotten at least 50 times the value from Vega-extra. Buy this now.Rating:85 out of100, 71Vega-extraNot able to tell you how happy I am with Vega-extra.Rating:83 out of100, 71Vega-extraVega-extra is worth much more than I paid. No matter where you go, Vega-extra is the coolest, most happening thing around! I wish I would have thought of it first.Rating:100 out of100, 71Vega-extraVega-extra is both attractive and highly adaptable. Vega-extra is exactly what our business has been lacking.Rating:79 out of100, 71Vega-extraI love your system. Vega-extra is worth much more than I paid. Vega-extra is worth much more than I paid.Rating:86 out of100, 71Vega-extraThanks guys, keep up the good work! Really good. I would like to personally thank you for your outstanding product. We've used Vega-extra for the last five years.Rating:83 out of100, 71Vega-extraVega-extra is the real deal! After using Vega-extra my business skyrocketed! I have gotten at least 50 times the value from Vega-extra.Rating:97 out of100, 71Vega-extraVega-extra is the next killer app. I was amazed at the quality of Vega-extra. We can't understand how we've been living without Vega-extra. We were treated like royalty.Rating:92 out of100, 71Vega-extraVega-extra is the next killer app. Very easy to use. I don't know what else to say.Rating:94 out of100, 71Vega-extraThis is simply unbelievable!Rating:79 out of100, 71Vega-extraThanks Vega-extra!Rating:86 out of100, 71Vega-extraIt fits our needs perfectly. Not able to tell you how happy I am with Vega-extra.Rating:93 out of100, 71Vega-extraI have gotten at least 50 times the value from Vega-extra.Rating:71 out of100, 71Vega-extraIt's the perfect solution for our business. Vega-extra has really helped our business. I will let my mum know about this, she could really make use of Vega-extra!Rating:91 out of100, 71Vega-extraReally good. Vega-extra is great.Rating:84 out of100, 71Vega-extraVega-extra is great.Rating:90 out of100, 71Vega-extraWithout Vega-extra, we would have gone bankrupt by now. Your company is truly upstanding and is behind its product 100%. Without Vega-extra, we would have gone bankrupt by now. I am really satisfied with my Vega-extra.Rating:99 out of100, 71Vega-extraIt's the perfect solution for our business. Thanks for the great service.Rating:83 out of100, 71Vega-extraThis is simply unbelievable!Rating:94 out of100, 71Vega-extraSince I invested in Vega-extra I made over 100,000 dollars profits.Rating:79 out of100, 71Vega-extraNice work on your Vega-extra. We've used Vega-extra for the last five years.Rating:78 out of100, 71Vega-extraThank you for making it painless, pleasant and most of all hassle free! It's the perfect solution for our business. We have no regrets!Rating:81 out of100, 71Vega-extraI will refer everyone I know.Rating:90 out of100, 71Vega-extraVega-extra is the real deal! Thanks Vega-extra!Rating:76 out of100, 71Vega-extraVega-extra should be nominated for service of the year. Great job, I will definitely be ordering again! I would also like to say thank you to all your staff. Just what I was looking for.Rating:88 out of100, 71Vega-extraWithout Vega-extra, we would have gone bankrupt by now. Your company is truly upstanding and is behind its product 100%. Without Vega-extra, we would have gone bankrupt by now. I am really satisfied with my Vega-extra.Rating:91 out of100, 71Vega-extraVega-extra is the next killer app. I would also like to say thank you to all your staff. I don't always clop, but when I do, it's because of Vega-extra. The best on the net!Rating:93 out of100, 71Vega-extraNeedless to say we are extremely satisfied with the results. I have gotten at least 50 times the value from Vega-extra. Thank you for making it painless, pleasant and most of all hassle free!Rating:94 out of100, 71Vega-extraDude, your stuff is the bomb!Rating:99 out of100, 71Vega-extraI use Vega-extra often.Rating:99 out of100, 71Vega-extraThanks to Vega-extra, we've just launched our 5th website! Best. Product. Ever! I can't say enough about Vega-extra. Nice work on your Vega-extra.Rating:96 out of100, 71Vega-extraJust what I was looking for. I'd be lost without Vega-extra. I just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone.Rating:79 out of100, 71Vega-extraAbsolutely wonderful! I am completely blown away. You've saved our business! Vega-extra is worth much more than I paid.Rating:88 out of100, 71Vega-extraVega-extra should be nominated for service of the year. I would be lost without Vega-extra. Thank you for making it painless, pleasant and most of all hassle free! I wish I would have thought of it first.Rating:89 out of100, 71Vega-extraThank you so much for your help. You've saved our business! It's just amazing. I am so pleased with this product.Rating:83 out of100, 71Vega-extraAfter using Vega-extra my business skyrocketed! I just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone.Rating:79 out of100, 71Vega-extraVega-extra has completely surpassed our expectations. We have no regrets!Rating:93 out of100, 71

Our bestsellers